AGER1 Counteracts Cellular Oxidant Stress Induced by AGEs via Negative Regulation of p66-dependent FKHRL1 Phosphorylation
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چکیده
Running Title: AGER1 inhibits p66 and FOXO-dependent Oxidant Stress Address correspondence to: Helen Vlassara, Division of Experimental Diabetes & Aging Brookdale Department of Geriatrics, Mount Sinai School of Medicine, Box 1640, One Gustave Levy Place, New York, NY 10019, Tel. 212-241-2567; Fax. 212-241-7248; E-Mail: [email protected] Page 1 of 25 Articles in PresS. Am J Physiol Cell Physiol (November 21, 2007). doi:10.1152/ajpcell.00350.2007
منابع مشابه
AGE-receptor-1 counteracts cellular oxidant stress induced by AGEs via negative regulation of p66shc-dependent FKHRL1 phosphorylation.
Advanced glycation end products (AGEs) promote reactive oxygen species (ROS) formation and oxidant stress (OS) in diabetes and aging-related diseases. AGE-induced OS is suppressed by AGER1, an AGE-receptor that counteracts receptor for advanced glycation end products (RAGE) and epidermal growth factor receptor (EGFR)-mediated Shc/Ras signal activation, resulting in decreased OS. Akt, FKHRL1, an...
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OBJECTIVE Increased oxidative stress (OS) and impaired anti-OS defenses are important in the development and persistence of insulin resistance (IR). Several anti-inflammatory and cell-protective mechanisms, including advanced glycation end product (AGE) receptor-1 (AGER1) and sirtuin (silent mating-type information regulation 2 homolog) 1 (SIRT1) are suppressed in diabetes. Because basal OS in ...
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